3 D islet graft histology : panoramic imaging of neural plasticity in sympathetic 1 reinnervation of transplanted islets under the kidney capsule 2 3
نویسندگان
چکیده
1 reinnervation of transplanted islets under the kidney capsule 2 3 Jyuhn-Huarng Juang, Shih-Jung Peng, Chien-Hung Kuo, and Shiue-Cheng Tang 4 5 Running title: 3D imaging of islet graft sympathetic reinnervation 6 7 1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung 8 Memorial Hospital, Taoyuan 33302, Taiwan 9 2 Department of Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan 10 3 Connectomics Research Center, National Tsing Hua University, Hsinchu 30013, Taiwan 11 4 Institute of Biotechnology, National Tsing Hua University, Hsinchu 30013, Taiwan 12 5 Biomedical Technology and Device Research Laboratories, Industrial Technology Research 13 Institute, Hsinchu 31040, Taiwan 14 6 Department of Medical Science, National Tsing Hua University, Hsinchu 30013, Taiwan 15 16 * Corresponding author 17 Tel.: + 886-3-574-2465 18 Fax: + 886-3-571-5934 19 E-mail address: [email protected] 20 21 Articles in PresS. Am J Physiol Endocrinol Metab (January 14, 2014). doi:10.1152/ajpendo.00515.2013
منابع مشابه
Three-dimensional islet graft histology: panoramic imaging of neural plasticity in sympathetic reinnervation of transplanted islets under the kidney capsule.
Microscopic examination of transplanted islets in an ectopic environment provides information to evaluate islet engraftment, including revascularization and reinnervation. However, because of the dispersed nature of blood vessels and nerves, global visualization of the graft neurovascular network has been difficult. In this research we revealed the neurovascular network by preparing transparent...
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Grafted islets become denervated due to the islet transplantation procedure. The aim of the present study was 1) to examine whether islet grafts in the liver, the spleen, and under the kidney capsule in rats become reinnervated following the transplantation and experimental procedures used in our laboratory, 2) whether there is any difference in reinnervation at these different sites, and 3) ho...
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